Model and Strategy
Schizophrenia (SZ) is a persistent illness characterized by psychosis (loss of sense of reality) and cognitive deficits. SZ ranks among the top 10 causes of disability worldwide; only 1 out of 7 patients will experience recovery. We now know that cognitive deficits are more predictive of poor long-term social and occupational outcome than psychosis symptoms.
Neuroplasticity based cognitive training in SZ is a highly innovative treatment that drives significant cognitive gains in patients. Critically, cognitive gains as well as brain plasticity changes correlate with improvements in real-world functioning. We have tested this approach in young people with early psychosis and shown that we can reverse impaired cognition and symptom progression. However, access and adherence are key challenges. This project will meet these challenges by providing cognitive training entirely remotely via a mobile device, along with an innovative mobile app designed to enhance treatment engagement.
Impact
We now have sixmonth followup data showing that young people recently diagnosed with SZ who undergo training, also have lower symptoms (fewer hallucinations and delusions) and better functioning over the longerterm.
If this finding is replicated in the present study, using a highly scalable technology that can be delivered remotely, the longterm positive impact on large numbers of individuals throughout the U.S. (and elsewhere), their family members, and their communities is beyond measure.
Leadership
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Sophia Vinogradov
ViceChair, UCSF Department of Psychiatry